Lisele tse tšoaelitsoeng morao tjena li na le HIV-1 proviral DNA genome haholo-holo e kopantsoeng ho heterochromatin, e leng se lumellang ho tsoela pele ha li-provirus tse khutsitseng.Hypoacetylation of histone proteins by histone deacetylases (HDAC) e ameha ho bolokeheng ha latency ea HIV-1 ka ho hatella transcription ea kokoana-hloko.Ho feta moo, mafu a periodontal, a bakoang ke libaktheria tsa polymicrobial subgingival ho akarelletsa le Porphyromonas gingivalis, ke a mang a mafu a atileng haholo molokong oa batho.Mona re bonts'a litlamorao tsa P. gingivalis ho ikatisa ea HIV-1.Ketsahalo ena e ka amahanngoa le setso sa baktheria se phahametseng tlhaho empa eseng ho likarolo tse ling tsa baktheria tse kang fimbriae kapa LPS.Re fumane hore ts'ebetso ena ea ts'oaetso ea HIV-1 e ile ea fumanoa karolong e tlaase ea molek'hule (<3 kDa) karolo ea setso sa supernatant.Re ile ra boela ra bontša hore P. gingivalis e hlahisa metsoako e phahameng ea butyric acid, e sebetsang e le inhibitor e matla ea HDAC le ho baka histone acetylation.Litlhahlobo tsa Chromatin immunoprecipitation li senotse hore "corepressor complex" e nang le HDAC1 le AP-4 e ne e arohane le "HIV-1" ea nako e telele ea ho pheta-pheta ka mor'a ho susumetsoa ke "bacterial culture supernatant" hammoho le mokhatlo oa acetylated histone le RNA polymerase II.Kahoo re fumane hore P. gingivalis e ka etsa hore HIV-1 e tsosolosoe ka chromatin modification le hore butyric acid, e 'ngoe ea metabolites ea baktheria, e ikarabella bakeng sa phello ena.Liphetho tsena li fana ka maikutlo a hore mafu a periodontal a ka sebetsa e le sesosa sa kotsi ea hore HIV-1 e tsosolose batho ba tšoaelitsoeng 'me e ka kenya letsoho ho phatlalatseng kokoana-hloko.
Nako ea poso: Sep-10-2020